Antidepressant discontinuation syndrome is common
Two studies reported a higher risk of discontinuation symptoms with abrupt termination
A review of the adverse events associated with the use of bupropion spontaneously reported to Glaxo Wellcome Inc
Advise patients that the excessive use or abrupt discontinuation of alcohol, benzodiazepines, antiepileptic drugs, or sedatives/hypnotics can increase the risk of seizure
ingredient in the study medications or undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines)
Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with Major Depressive Disorder
Depressed mood or motivation may take up to 6-8 weeks to fully improve
Adverse neuropsychiatric events or reduced alcohol tolerance reported rarely with concomitant use of alcohol and bupropion
Instruct patients to discontinue and not restart bupropion hydrochloride extended-release (SR) tablets if they experience a seizure while on treatment
Bupropion hydrochloride extended-release tablets (XL) is contraindicated in patients with a seizure disorder or conditions that increase the risk of seizure (e
However, if you usually drink a lot of alcohol, speak with your doctor before stopping abruptly
Gradually reducing the dose over 4 weeks can help to prevent severe withdrawal
About 20% of patients develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant taken continuously for one month
A recent study supports the use of combination therapy with bupropion and extended-release naltrexone intramuscular injection in reducing
It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), Cipro®), and abrupt discontinuation of benzodiazepines (e
immediate release formulation of bupropion